Study Schema (click to enlarge)
Lung cancer in never-smokers is the 7th most common malignancy worldwide. Environmental and inherited causes in never-smokers remain uncertain, as well as in other populations without an identifiable risk factor. Lung cancer in never-smokers has recently been found identifiable in family members carrying inherited EGFR gene mutations, called T790M. Understanding underlying biology in high-risk families will provide insight into why lung cancer occurs in never-smokers and others; however, such families have been too rare to study systematically. INHERIT launched in early December 2012. ALCMI is coordinating tissue collection/analysis and CT-scan banking. Patients with T790M mutation tumors are being tested for underlying inherited T790M mutations and family members are also being recruited. Creating a registry of high-risk families is laying the groundwork for subsequent lung cancer screening and prevention research, irrespective of smoking history.
Understanding underlying biology in high-risk families will provide insight into why lung cancer occurs in never-smokers and others without apparent causations.
Using ALCMI’s network of cancer centers and other referrals, patients with tumors carrying the T790M mutation will be tested for underlying inherited T790M mutations; family members of affected patients can then be studied.
– Mutation (EGFR T790M) testing and genetic counseling
– Creates registry of high-risk families
– Ability to study other rare populations